Caracterização histopatológica da cicatrização de lesões cutâneas induzidas em Rattus Novergicus tratadas com pomada à base de óleo de pequi

Abstract

Cutaneous wound healing involves a dynamic sequence of cellular and molecular events that can be modulated by bioactive natural compounds. In this context, the healing effect of an ointment containing 10% pequi oil (Caryocar coriaceum Wittm) was evaluated in experimentally induced skin lesions in Wistar rats (Rattus novergicus) through histopathological analysis. Fifteen animals were divided into three experimental groups and assessed at 4°, 7° and 14° days post-surgery. On day 4, the acute inflammatory phase predominated, characterized by intense cellular infiltration, fibrin-hemorrhagic crust formation, and vascular congestion. By day 7, a reduction in inflammatory response and increased granulation tissue formation were observed, indicating progression to the proliferative phase. At 14 days, improved re-epithelialization, collagen deposition and remodeling, and a markeddecrease in inflammatory signs were noted. These findings suggest that the pequi oil-based ointment promotes inflammation modulation and supports effective tissue repair.