Infusão alvo controlada de Propofol em cães e gatos: uma revisão sobre farmacocinética e modelos preditivos

Abstract

Target-controlled infusion (TCI) represents an advancement in veterinary anesthesiology, allowing for the precise administration of intravenous drugs based on pharmacokinetic models. Propofol, due to its lipophilic characteristics, rapid distribution, and short duration of action, is the compound of choice for this infusion modality. This study aimed to conduct a narrative literature review on the use of TCI with propofol in dogs and cats, addressing its principles, available pharmacokinetic models, and clinical applications. This infusion modality allows for the maintenance of stable drug concentrations in plasma. Cattai's pharmacokinetic models show clinically acceptable predictive performance for dogs and cats. This infusion model offers advantages such as smooth induction, rapid recovery, and a lower incidence of adverse effects. The limitations of this technique are associated with the generalization of the pharmacokinetic profile of the models applied to the population. TCI with propofol proves to be a safe and effective technique, providing greater predictability and anesthetic quality in small animals.